On Tuesday, Chicago Cubs manager Rick Renteria became the first manager of the the season to be ejected. Renteria was ejected in the top of the ninth inning when arguing balls and strikes. The Cubs would go on to lose the game to the Pittsburgh Pirates on Tuesday 7-6.
- The Pirates touched up Cubs starting pitcher Edwin Jackson for 4 runs in the first inning. After the Cubs scored 4 runs between the second and third innings, the game was briefly tied at 4. The game was tied until Jackson allowed single runs in the fourth and fifth innings; giving the Pirates a 6-4 lead. The Cubs followed suit and scored a run in each the sixth and seventh inning to tie the game at 6. In the eighth inning is when the Pirates scored the decisive run of the game.
- Jackson struggled on Tuesday. Jackson allowed 6 runs on 9 hits and 4 walks in 4 2/3 innings of work against the Pirates on Tuesday.
- Jose Veras had his best outing of the season on Tuesday. Veras pitched a perfect ninth inning frame while throwing only 14 pitches.
- Starlin Castro had a pair of home runs for the Cubs on Tuesday. Castro was 3-for-4 on Tuesday with 2 home runs and 4 RBIs.
- Emilio Bonifacio continued his hot start to the season. Bonifacio was 3-for-5 in the Cubs loss to go along with a RBI and a run scored.
- Anthony Rizzo was also productive on Tuesday as the first baseman went 2-for-3 with a walk as well as a RBI and a run scored.