With a 5-4 loss to the Indians, the Sox’s 13 game skid reached a club record for consecutive losses against a single team.
Dayan Viciedo and Alejandro De Aza hit home runs in the ninth inning off Indians closer Chris Perez but it was not enough as Indians’ Jason Giambi hit a pinch-hit, two-run walk-off home run off Sox closer Addison Reed to give the Indians a victory.
Sox center fielder Alejandro De Aza added a RBI single in the seventh off Indians starter Ubaldo Jimenez (12-9, 3.39 ERA) to push the Sox ahead 2-1.
The Sox have five games remaining in their 2013 season and must win at least on to avoid 100 losses.
Santiago allowed six hits and three earned runs, struck out one and walked two in 6 1/3 innings.
Jimenez also went 6 1/3 innings, gave up five hits and two earned runs, struck out seven and walked three.