Quintana allowed one earned run on eight hits in six innings. He struck out five and walked two for a 4-1 lead, and the Sox bullpen held on to avoid Quintana falling to an 18th no-decision of the season.
The Sox won their fifth straight game against the Twins and their fifth home series in their last eight.
Trevor Plouffe answered with an RBI double in the third inning to tie it at 1-1.
Alejandro De Aza‘s single, Alexei Ramirez‘s RBI double, and Dayan Viciedo‘s RBI single in the fifth inning extended the Sox lead to 3-1. Viciedo added another run in the sixth inning for a 4-1 Sox lead.
Pelfrey gave up nine hits and three earned runs, walked one and struck out six in just 4 1/3 innings.
In the seventh inning, Plouffe hit a sharp ground ball off Sox reliever Jake Petricka‘s glove for an RBI single to cut the Sox lead to 4-2. With runners at first and second, Oswaldo Arcia hit a grounder, which Ramirez went to second for the force out. Gordon Beckham‘s relay to first went past Paul Konerko at first, allowing another Twins run to score.
Addison Reed pitched a scoreless ninth inning for his 38th save of the season.