Albers (2-1, 1.85 ERA) came into the night undefeated with a perfect earned-run average after 17 1/3 innings in two starts on Aug. 6 and Aug. 12.
With two outs in the fourth inning Dayan Viciedo hit a three-run homer off Albers proved to be the difference in the Sox win.
The Sox jumped out a 1-0 lead in the first inning. Alejandro De Aza singled, Alexei Ramirez doubled and De Aza scored on Paul Konerko’s groundout to short.
The Twins got four straight hits off Sox starter Chris Sale (9-11, 2.78 ERA) with two outs to take a 3-1 lead. Joe Mauer nearly hit a solo home run to center that fell to a double to score Pedro Florimon and Brian Dozier. Josh Willingham doubled to left-center to score Mauer.
Adam Dunn and Avisail Garcia hit back-to-back doubles before Dayan Viciedo homered to give the Sox a 5-3 lead in the fourth. Garcia’s line drive double to left scored Dunn to cut the deficit to 3-2, Albers then walked Jeff Keppinger, and Viciedo hit a 390 feet three-run home run to left.
In the eighth inning, Dunn doubled to left to score De Aza to increase the Sox lead to 6-3.
The Twins then cut the Sox lead to 6-5 with a Ryan Doumit two-run home run to score Willingham.
De Aza hit a two-run home run to right in the ninth to score Jordan Danks for extra measure.
Sale went seven innings, allowing nine hits and three earned runs, and struck out eight and walked one. Albers gave up eight hits and five earned runs, struck out three and walked one in seven innings.
Sox third baseman Conor Gillaspie was out of the starting lineup with a bruised left hand he suffered Friday night in the eighth inning.
Sox left-hander Hector Santiago (3-7, 3.37 ERA) and Twins right-hander Deuno (7-6, 3.54 ERA) are the projected starters at Target Field for Sunday afternoon’s game at 1:10 p.m. CT (CSN, WSCR 670).