Konerko returned on July 22 from a lower back injury in a designated hitter role and has yet to see action at first base.
The 6-1 loss in Cleveland extended the Sox’s losing streak to seven and saw them fall 26 games below .500.
The Indians got on the board first in the second inning with a two-out RBI single by Mark Reynolds off left hander Chris Sale. Reynolds’ RBI snapped his 51 consecutive at-bats without an RBI.
The Tribe kept rolling in the third with a Ryan Raburn wind-aided two-run home run to right with one out to give the Indians an early 3-0 lead.
Raburn would extend the Indians’ lead in the fifth with a chopper off Connor Gillaspie’s glove to give them a 4-0 lead. Asdrubal Cabrera then flew out to center for, former Sox outfielder, Nick Swisher to score. Following another Indians’ single, Sale struck out Michael Brantley and Reynolds to end the inning.
Raburn added a solo home run for extra measure in the seventh. Raburn’s second home run on the afternoon was his 13th this season and second multiple home-run game this season.
The Indians’ collected a season-high 10 hits off Sale. Sale is now 0-3 in three starts this season against Cleveland with a 8.31 ERA.
Alejandro De Aza hit a home run in the sixth off Masterson for the Sox’s lone run on the afternoon.
The Sox return to action tomorrow in Detroit at 6:08 p.m. (CSN).